Assessment of Breast Cancer Response to Neoadjuvant Chemotherapy: a Radiologist’s Perspective

Panagiotis Kapetas, Katja Pinker, Thomas Helbich


Neoadjuvant chemotherapy (NAC) plays a central role in the management of breast cancer (BC) patients, especially (but not exclusively) in cases of locally advanced cancers, to achieve operability. A wide spectrum of imaging modalities is used to evaluate BC response to NAC (mammography, digital breast tomosynthesis, ultrasound, magnetic resonance imaging, nuclear medicine imaging, optical imaging, etc.), providing not only morphological, but also functional and molecular information. This review aims to provide radiologists with an overview of the current knowledge and perspectives regarding the role of different imaging techniques in the assessment and prediction of BC response to NAC.


breast cancer; chemotherapy; neoadjuvant therapies; diagnostic imaging; multimodal imaging

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