Computed tomography-guided mediastinal biopsy: a single center’s experience focusing upon efficacy and safety

Dimitrios Filippiadis, Danai E. Stefanou, Argyro Mazioti, Alexios Kelekis, Efthymia Alexopoulou, Elias Brountzos, Nikolaos Kelekis


Purpose: The purpose of this study is to evaluate the efficacy and safety of Computed Tomography (CT)-guided mediastinal biopsy.

Material and Methods: This is a single centered retrospective study including 32 mediastinal biopsies performed during the last 24 months in a cohort of 29 patients (15 male-14 female, average age 57 years, lesions diameter ranging between 2-12 cm); 3 patients underwent  a second biopsy due to insufficient sample post the first attempt . All percutaneous biopsies were performed under local anaesthesia and CT guidance; in all cases an 18G semi-automatic soft tissue biopsy needle was used for tissue sampling.  CT scan was used for evaluation of potential complications.

Results: The histological outcome was conclusive for 26/29 patients (89.6%), whilst post the second attempt efficacy rate increased to 93.7% (27/29 patients - 30/32 biopsies). Biopsy reports included lymphoma (14 cases), bronchogenic carcinoma (10 cases), metastasis (1 case) and benign substrate (2 cases). The mean ionising rate per CT-guided biopsy was 14mGy. No complications were noted in this study according to the CIRSE classification system.

Conclusions: Imaging-guided percutaneous needle biopsy of mediastinal masses is a safe and effective technique for diagnosis of suspicious lesions. Imaging guidance and correct route selection increase efficacy and safety rates.


Computed Tomography; biopsy; mediastinum; safety; efficacy

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