Pseudoexfoliation syndrome: Gray matter volume and microstructural changes revealed by histogram and brain surface analysis

Christos V Gkizas, Loukas G Astrakas, Anastasia K Zikou, Vasileios G Xydis, George Kitsos, Maria I Argyropoulou

Abstract


Purpose: White matter (WM) abnormalities may occur in patients with pseudoexfoliation syndrome (PXS). The presence of gray matter (GM) abnormalities in patients with PXS without glaucoma was evaluated, applying histogram and brain surface analysis of MRI data.

Material and Methods: Brain MRI was conducted on 20 patients newly diagnosed with PXS without glaucoma, (mean age 68.7 ± 8.6 years) and 14 control subjects (mean age 63.3 ± 6.6 years). The histogram scalars of mean diffusivity (MD) and fractional anisotropy (FA) of GM and WM were evaluated. Brain surface analysis was performed on 3D T1-weighted images.

Results: The MD value of the WM showed higher mean, standard deviation, median and 75th percentile in the patients than in the control subjects. The FA values of GM showed higher mean, standard deviation, median and 75th percentile, and lower kurtosis and skewness in the patients than in the control subjects. Greater GM volume was observed in the patients in Brodmann areas 25 and 26.

Conclusions: Patients with PXS may present microstructural changes of the GM that could be associated with the deposition of extracellular fibrillar material and increased cortical volume in areas related to depression. 


Keywords


Pseudoexfoliation syndrome; Diffusion tensor imaging; Histogram analysis; Cortical surface analysis; MR imaging; Brain

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References


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DOI: http://dx.doi.org/10.36162/hjr.v5i3.373

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