X-ray radiation affects the protection filter of yellow-tinted acrylic hydrophobic intraocular lenses against harmful UV-A and blue light

Ellas Spyratou, Ioannis Antonakos, Georgios Kareliotis, Constantinos Bacharis, Efstathios Petros Efstathopoulos

Abstract


Purpose: This study aims to investigate whether x-ray irradiation at doses delivered to the eye in plain radiography, CT and fluoroscopically guided procedures can affect the optical properties of yellow-tinted intraocular lenses (IOLs) implants in the near-Ultraviolet (UV-A) and visible (VIS) region.

Material and Methods: 5 yellow azodye doped IOL of different models and diopters were irradiated with x-rays ranging from 1.1 to 22.6 mGy. The transmission spectra of each IOL were recorded pre-irradiation and post-irradiation by using a light source for IOL illumination, a spectraflect-coated integration sphere for the spectrum collection and a UV/VIS spectrometer for the spectrum record.

Results: According to the recorded spectra, the transmittance of all the yellow-tinted IOLs increases systematically in the UV-A and blue light region as the irradiation dose increases. A linear dependence is recorded between the percentage increase of the transmittance and the increase in the irradiation dose at 380 nm.


Keywords


X-ray radiation; Intraocular lenses; Transparency; Protective filter

Full Text:

PDF

References


Sen HN, Sarikkola A U, Uusitalo RJ, et al. Quality of vision after AMO Array multifocal intraocular lens implantation. J Cataract Refract Surg 2004; 30: 2483–2493.

Javitt JC, Steinert R F. Cataract extraction with multifocal intraocular lens implantation: a multinational clinical trial evaluating clinical functional, and quality-of-life outcomes. Opthalmology 2000; 107: 2040–2048.

Kraff MC, Sanders D, Lieberman H L. Serial corneal endothelial cell loss with lathe-cut and injection-molded posterior chamber intraocular lenses. J Am Intraocul Implant Soc 1983; 93: 301–305.

Linetsky M, Raghavan CT, Kaid J, et al. UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem 2014; 289: 17111-23.

Sathyan S. Advanced technology intraocular lenses: Current trends. Kerala J Ophthalmol 2020; 3:112.

Ardjomand N, Wirtitsch M G, Wenzl E. Yellow Intraocular lenses-to block or not to block. European Ophthalmic Review 2009; 3: 77-9.

Foster A. VISION 2020: The cataract challenge. Community Eye Health 2000; 13: 17–19

Ellerin BE, Nisce L Z, Roberts C W, et al. The effect of ionizing radiation of intraocular lenses. Int J Radiation Oncology Biol Phys 2001; 51: 184–208.

Pratt CM, Barton S, McGonigle E, et al. The effect of ionising radiation on poly (methyl methacrylate) used in intraocular lenses Polymer Degradation and Stability 2006; 91: 2315-2317.

Spyratou E, Antonakos I, Platoni K, et al. Investigating the Effect of Ionizing Radiation on Intraocular Lenses at Clinical Doses. Insights Med Phys 2017; 2: 1-5.

Moritake T, Matsumaru Y, Takigawa T, et al. Dose measurement on both patients and operators during neuro interventional procedures using photoluminiscence glass dosimeters. AJNR Am J Neuroradiol 2008; 29: 1910–17

Sánchez RM, Vañó, E, Fernández J M, et al. Radiation Doses in Patient Eye Lenses during Interventional Neuroradiology Procedures AJNR Am J Neuroradiol 2016; 37: 402-407

Vanhaverea F, Carinoub E, Domienikc J, et al. Measurements of eye lens doses in interventional radiology and cardiology: Final results of the ORAMED project Radiation Measurements 2011; 46: 1243-1247.

Sarna T, Rozanowska M. Phototoxicity to the eye. In: Jori G, Pottier RH, Rodgers MAJ, Truscott TG (eds) Photobiology in Medicine. New York: Plenum Press; 1994, pp125-142.

Glickman RD. Phototoxicity to the Retina: Mechanism of Damage. International Journal of Toxicology. 2002; 21: 473–490.

Akinay A, Ong MD, Choi M, et al. Measuring ultraviolet-visible light transmission of intraocular lenses: Double-beam mode versus integrating-sphere mode. J Biomed Opt 2012; 17: 105001-105007.

Peak JG, Peak M J. Comparison of initial yields of DNA-to protein crosslinks and single-strand breaks induced in cultured human cells by far- and near-ultraviolet light, blue light and X-rays. Mutat Res 1991; 246: 187-191.

Chen P, Lai Z, Wu Y, et al. Retinal Neuron Is More Sensitive to Blue Light-Induced Damage than Glia Cell Due to DNA Double-Strand Breaks. Cells 2019; 8: 68-82.

Narimatsu T, Ozawa Y, Miyake S, et al. Biological effects of blocking blue and other visible light on the mouse retina. Clin Exp Ophthalmol 2014; 42: 555-63.

Rauf MA, Ashraf S S. Radiation induced degradation of dyes-An overview. Journal of hazardous materials 2008; 166: 6-16.

International Commission on Radiological Protection, Managing Patient Dose in Computed tomography, in Ann ICRP 2000 Pergamon Oxford, 2000d, ICRP Publication 87, Vol. 30, Issue 4.

Perisinakis K, Raissaki M, Theocharopoulos N, et al. Reduction of eye lens radiation dose by orbital bismuth shielding in pediatric patients undergoing CT of the head: a Monte Carlo study. Med Phys, 2005; 32: 1024-30.

Raissaki M, Perisinakis K, Damilakis J, et al. Eye-lens bismuth shielding in paediatric head CT: artefact evaluation and reduction. Pediatr Radiol 2010; 40: 1748-54.

Lee YH, Yang SH, Lin YK, et al. Eye Shielding During Head CT Scans: Dose Reduction and Image Quality Evaluation. Acad Radiol 2020; 27: 1523-1530.

Fontenla DP, Ahmad M, Chui CS, et al. Effect of ocular implants of different materials on the dosimetry of external beam radiation therapy. Int J Radial Oncol Biol Phys 1995; 32: 1477–1480.

Downes S M. Ultraviolet or blue-filtering intraocular lenses: What is the evidence? Eye 2016; 30: 215-21.




DOI: http://dx.doi.org/10.36162/hjr.v6i3.426

Refbacks

  • There are currently no refbacks.